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MicroRNA-21 (miR-21) is an oncogenic miRNA that targets the tumor suppressor PTEN and plays a key role in the development of many tumors, including head and neck cancers. However, its role in oral squamous cell carcinoma (OSCC) remains largely unknown. In this study, we examined the expression levels of miR-21 in OSCC tissues and the relationships between its expression and clinical features in patients with recurrent and advanced OSCC. The expression levels of miR-21 were assessed in OSCC cell lines and primary OSCC tumors. The relationships between miR-21 expression levels and clinicopathological features and patient survival were analyzed in OSCC. The expression levels of miR-21 were significantly higher in OSCC cell lines and primary OSCC tumors than in normal oral tissues. The expression levels of miR-21 in the patients with recurrent and advanced OSCC were higher than in those without recurrence and metastasis. Moreover, in the patients with advanced OSCC, miR-21 expression levels were correlated with gender, smoking history, tumor differentiation, tumor stage, nodal metastasis and recurrence. In addition, the patients with high miR-21 expression had poorer survival than those with low miR-21 expression. Our findings suggest that miR-21 upregulation may be an important factor in the recurrence and metastasis of OSCC.Follicular bronchiolitis with fibrosis in human 0b46394aab