"Sevilla are very experienced in the Europa League and have won it so many times," said United boss Ten Hag.
"We have to be aware of it."
Ten Hag's side, who won last month's Carabao Cup, are also still in the FA Cup and host Fulham in the quarter-finals of that competition on Sunday (16:30 GMT).
Europa League quarter-final draw
Manchester United v Sevillaเว็บพนัน ufabet
Juventus v Sporting Lisbon
Bayer Leverkusen v Union Saint-Gilloise
Feyenoord v Roma
Europa League semi-final draw
Juventus or Sporting Lisbon v Manchester United or Sevilla
Feyenoord or Roma v Bayer Leverkusen or Union Saint-Gilloise